The relationship between serum levels of miR-342 and miR-148a and acute lung injury in sepsis patients

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Objectives To investigate the relationship between serum miR-342, miR-148a, and acute lung injury (ALI) in sepsis patients. Methods A total of 177 sepsis patients were divided into ALI and non-ALI groups; ALI patients were further classified as mild, moderate, or severe. 162 pneumonia patients served as controls. Serum miR-342 and miR-148a levels were measured using RT-qPCR. Results Sepsis patients had lower miR-342 and higher miR-148a than controls (p Conclusions Sepsis patients with ALI exhibit low serum miR-342 and high miR-148a, and their combination can effectively predict ALI occurrence.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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