Research highlights on stem cell therapy for the treatment of Peyronie's disease.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

New treatment modalities have been developed to improve the treatment outcomes of Peyronie's disease (PD). Stem cells are undifferentiated cell populations that are capable of self-renewal and of differentiation into various kinds of cells or new tissues. In addition, stem cells also have antiapoptotic, antifibrotic, and immunomodulatory properties. The results from preclinical studies support the potential role of adipose-derived stem cells (ADSCs) therapy for both the prevention and treatment of PD. However, there are several limitations of the animal model used in the studies. Further animal and clinical studies are still needed to validate the therapeutic effects and clinical application of ADSCs for the treatment of PD.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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