[Research progress of adipose-derived stem cells on refractory wounds].

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

To summarize the recent advances in the research of adipose-derived stem cells (ADSCs) for the treatment of refractory wounds. The related literature about using ADSCs for treating refractory wounds in recent years was reviewed, and their repair mechanism and treatment progress were summarized in detail. Tremendous progress has been achieved in using ADSCs in combination with single stent technology, sheet technology, and other methods to promote the healing of refractory wounds. ADSCs can accelerate wound angiogenesis and promote the healing of refractory wounds through its own mechanisms of paracrine, proangiogenic, anti-oxidative and apoptosis. With the advantages of adequate sources, easy to extract and culture, non-immune rejection, multidirectional differentiation potential, and significant angiogenic potential, ADSCs has become the ideal seed cells of tissue regeneration. However, it is necessary to improve stem cell transmission technology and develop biomaterials for clinical application in order to improve the refractory wounds healing. 总结近年脂肪来源干细胞（adipose-derived stem cells，ADSCs）应用于难愈性创面治疗中的研究进展。. 查阅近年有关 ADSCs 治疗难愈性创面的文献，分析总结其修复机制及治疗进展。. ADSCs 与单支架技术、片材技术等方法联合应用促进难愈性创面愈合已取得巨大进展，ADSCs 可通过自身旁分泌、促血管生成、抗氧化凋亡等多种机制，加快创面血管生成，促进难愈性创面愈合。. ADSCs 来源充足，易提取且易培养，无免疫原性，具有多向分化潜能和显著的促血管生成潜能，已成为再生医学理想的种子细胞。但仍需提高干细胞传递技术，开发更有利于临床使用的生物材料，以提高难愈性创面的治愈率。.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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