[Research progress on the relationship between non-coding RNA and liver regeneration]

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

After partial hepatectomy (PH) or liver injury, hepatocytes in a proliferating quiescent state are activated and begin to expand to repair the damaged liver. In recent years, studies have recognized that non-coding RNA (ncRNA) represented by microRNA (miRNA) and long non-coding RNA (lncRNA) can participate in liver regeneration by regulating the proliferation, apoptosis, autophagy, and proliferation and migration of hepatic progenitor cells (HPCs). This article reviews the relationship between miRNA, lncRNA, and liver regeneration, with a view to provide a new therapeutic strategies for liver disease and liver regeneration.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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