[Results of topical application of autologous regenerative products in hemorrhoidectomy].

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Hemorrhoidal disease (HD) is the most common proctological disorder. In the last decade, LigaSure and an ultrasound scalpel have been used for hemorrhoidectomy (HE). The problem of pain syndrome and prolonged discomfort in the postoperative period currently remains one of the main complications, despite minimal traumatization of tissues. This is related to prolonged healing under conditions of high microbial contamination and constant mechanical impact. The use of autologous regenerative products can solve this problem. To study the effect of topical application of platelet-rich autoplasma (PRP) and stromal vascular fraction (SVF) on wound healing rate, pain syndrome level and quality of life (QL) of patients after HE. The study included 90 patients with stage II-IV HD who underwent hemorrhoidectomy using LigaSure apparatus. Subjects of the 1st study group were administered with PRP to the postoperative wounds after the surgery, patients of the 2 nd study group - with SVF. In the control group, autologous regenerative agents were not administered. After the surgery, the cellular composition in the post-operative wounds was evaluated by cytology, pain syndrome level by the Visual Analogue Scale of Pain, QL by the EQ-5D-3L questionnaire. The change in the cellular composition of wounds in all groups demonstrates a natural dynamics of the wound process course. Nevertheless, an ear

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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