Revolutionizing bone regeneration and wound healing: Mechanical stromal vascular fraction and hyaluronic acid in a mouse calvarial defect model.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Introduction The stromal vascular fraction (SVF) is a complex and heterogeneous suspension derived from adipose tissue, containing both cellular and noncellular components. Its cellular fraction includes adipose-derived stem cells (ASCs), endothelial precursor cells, pericytes, macrophages, lymphocytes, and smooth muscle cells. The acellular "secretome" of SVF includes bioactive molecules such as growth factors, cytokines, chemokines, extracellular vesicles, and fragments of extracellular matrix (ECM), which contribute to its regenerative potential. Bone defeatures can be stimulated by mesenchymal stem cells (MSCs) that differentiate into osteoblast to support the healing and repair process. In addition to its cell content, the SVF is rich in growth factors, cytokines and chemokines, extracellular vesicles, and extracellular matrix components, which could stimulate regenerative processes through a trophic effect. Studies showed that hyaluronic acids are usually involved in healing processes. This study was focused on the healing potency of stromal stem cells isolated from adipose tissues by mechanical digestion, and the role of low-molecular-weight hyaluronic acid (LMW-HA, ACP) in the healing process was tested in calvarial defeatures in a mouse model, in comparison with the enzymatic digestion method. Methods The bone healing and remodeling process was evaluated in vivo using

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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