Role of adipose-derived stem cell exosomes in paclitaxel-induced acute ovarian injury: An experimental approach.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Paclitaxel (PTL) is commonly used in cancer therapy at varying doses and durations, often in combination with other chemotherapeutic agents. However, achieving therapeutic efficacy typically requires high doses, which are associated with considerable toxicity. Adipose-derived stem cells have shown therapeutic potential, particularly through the release of extracellular vesicles known as exosomes. This study investigated the potential protective effects of exosomes derived from adipose-derived mesenchymal stem cells (AMSC-Exos) in a rat model of PTL-induced acute ovarian injury. Twenty-eight rats were assigned to groups: control, PTL (7.5 mg/kg), AMSC-Exos (1 ×10 6 exosomes), and PTL+AMSC-Exos (7.5 mg/kg PTL + 1 × 10 6 exosomes). Three days after the administration, ovarian tissues were harvested for histological and biochemical analysis. Hematoxylin and eosin (H&E) and Masson's Trichrome (MT) staining revealed significant histopathological deterioration in the cortex and medulla of ovarian tissue in the PTL group compared to the PTL+AMSC-Exos group. Exosome treatment following PTL administration resulted in upregulation of VEGF and downregulation of HIF-1α, NF K B-p65, and IL-1β immunostaining intensities. Additionally, AMH immunostaining intensity was increased in primary, preantral, and secondary follicles. Levels of TNF-α, IL-1β, and IL-6 were significantly lower in the exos

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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