[Role of adipose tissue in the development and progression of colorectal cancer].

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The paper gives the current data available in the literature on the relationship and pathogenetic mechanisms of influence of adipose tissue on colorectal carcinogenesis. It considers the aspects of changes in adipose tissue and microenvironment of the tumor itself, including those under the influence of biologically active substances secreted by adipocytes; differences in subcutaneous and visceral fat and their importance in the development and progression of colorectal cancer (CRC), as well as the role of adipose tissue-derived stem cells. Understanding these mechanisms for adipose tissue influence on CRC will assist not only in preventing this disease, but also in searching for new therapeutic targets. Представлены современные данные литературы о взаимосвязи и патогенетических механизмах влияния жировой ткани на канцерогенез колоректального рака (КРР). Рассматриваются аспекты изменения жировой ткани и микроокружения самой опухоли, в том числе под влиянием биологически активных веществ, выделяемых адипоцитами; отличия подкожного и висцерального жира и их значение в становлении и прогрессировании КРР, а также роль стволовых клеток жировой ткани. Понимание данных механизмов влияния жировой ткани на КРР поможет не только профилактике данного заболевания, но и поиску новых терапевтических мишеней.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.