The Role and Mechanism of Nanozymes in Burn Wound Healing

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The treatment of burn wounds is a complex and lengthy process, including infection control, inflammation modulation, tissue regeneration, and scar management. Although significant progress has been achieved, numerous clinical challenges persist, especially the increased bacterial resistance, the risk of wound sepsis, and the issue of serious hypertrophic scar. In recent years, nanozymes have emerged as a hotspot in materials research and increasingly been applied to promote burn wound healing. Possessing multiple enzyme-like activities, nanozymes can integrate antibacterial, anti-inflammatory, and pro-angiogenic effects, among others. Meanwhile, nanozymes offer advantages such as less prone to inducing drug resistance, high stability, and simple preparation, which indicate broad application prospects compared with antibiotics, natural enzymes, and traditional nanomaterials. This review provides a comprehensive overview of the pathophysiology involved in burn wounds and introduces nanozymes exhibiting a variety of enzyme-like activities including oxidase (OXD), peroxidase (POD), superoxide dismutase (SOD), catalase (CAT), haloperoxidase (HPO), nitrite reductase (NiRs), and hydrolase. The potential mechanisms by which nanozymes promote burn wound healing are summarized and elucidated from the aspects of anti-bacteria, anti-oxidative stress, anti-inflammation, pro-angiogenesis, an

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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