Level D· Scientific groundwork from lab and animal studiesAnimal StudyEurope PMCOpen access

Severity, distribution and postoperative therapy are not predictors of return to work in western performance horses with stifle chondromalacia

Esselman AM., Johnson SA., Hague BA., Frisbie DD.

Animal Study with a reported sample of 34 on Hip, published in Vet Surg (2025) — summary generated from the PubMed abstract.

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Level D· Scientific groundwork from lab and animal studiesEvidence level of this study

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Animal Study
Journal
Vet Surg (2025)
Reported sample size
34
Source database
Europe PMC
PMID
40059430
PMCID
PMC12282042
DOI
10.1111/vsu.14196
Citations
1

Abstract (original English)

Objective (1) To evaluate the ability of western performance horses diagnosed with chondromalacia to return to performance; Specifically, the relationship between the grade of chondromalacia and the horses' ability to resume work; (2) To determine the impact of postoperative therapy on clinical outcomes. Study design Retrospective case series. Animals Horses (n = 34). Methods Records of western performance horses with lameness localized to the stifle that underwent subsequent arthroscopy with chondromalacia as the most significant diagnosis were reviewed. Chondromalacia was surgeon-graded as slight, mild, moderate, or marked. Three evaluated categories of postoperative intra-articular therapy included: (1) bone marrow derived mesenchymal stem cells, (2) equine amniotic allograft product or (3) none. Outcome was defined as returning to previous level of work on a numeric scale (1-10). Results Chondromalacia and its degree of severity and focal vs. diffuse distribution identified arthroscopically did not show a significant association (p = .54, .40, respectively) or correlation (p = .18; R-value: 0.27) with the ability to return to athletic performance. The type of postoperative intra-articular therapy did not have any association with the horse returning to athletic work (p = .53). Conclusion A statistically significant association between severity, distribution or subsequent po

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

How we grade evidence
StifleAnimalsHorsesHorse DiseasesLameness, AnimalArthroscopyTreatment OutcomeRetrospective StudiesFemaleMale

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