Severity, distribution and postoperative therapy are not predictors of return to work in western performance horses with stifle chondromalacia
Esselman AM., Johnson SA., Hague BA., Frisbie DD.
Animal Study with a reported sample of 34 on Hip, published in Vet Surg (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Vet Surg (2025)
- Reported sample size
- 34
- Source database
- Europe PMC
- PMID
- 40059430
- PMCID
- PMC12282042
- DOI
- 10.1111/vsu.14196
- Citations
- 1
Abstract (original English)
Objective (1) To evaluate the ability of western performance horses diagnosed with chondromalacia to return to performance; Specifically, the relationship between the grade of chondromalacia and the horses' ability to resume work; (2) To determine the impact of postoperative therapy on clinical outcomes. Study design Retrospective case series. Animals Horses (n = 34). Methods Records of western performance horses with lameness localized to the stifle that underwent subsequent arthroscopy with chondromalacia as the most significant diagnosis were reviewed. Chondromalacia was surgeon-graded as slight, mild, moderate, or marked. Three evaluated categories of postoperative intra-articular therapy included: (1) bone marrow derived mesenchymal stem cells, (2) equine amniotic allograft product or (3) none. Outcome was defined as returning to previous level of work on a numeric scale (1-10). Results Chondromalacia and its degree of severity and focal vs. diffuse distribution identified arthroscopically did not show a significant association (p = .54, .40, respectively) or correlation (p = .18; R-value: 0.27) with the ability to return to athletic performance. The type of postoperative intra-articular therapy did not have any association with the horse returning to athletic work (p = .53). Conclusion A statistically significant association between severity, distribution or subsequent po
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.
Related research
- Level ASystematic ReviewPubMed
Adipose-Derived Stem Cells in Traumatic Brain Injury: A Systematic Review of Preclinical Studies.
Systematic Review on Neuroinflammation, published in Tissue Eng Regen Med (2026) — summary generated from the PubMed abstract.
- 2026
Tissue Eng Regen Med - Level AMeta-analysisPubMed
Comparative efficacy of different doses of mesenchymal stem cells derived from different tissue sources for knee osteoarthritis: a systematic review and network meta-analysis of randomized controlled trials.
Meta-analysis with a reported sample of 602 on Knee Osteoarthritis, Osteoarthritis, Chronic Inflammation, Immune Modulation, published in PeerJ (2026) — summary generated from the PubMed abstract.
- 2026
- n = 602
PeerJ - Level AMeta-analysisPubMed
Efficacy of Stem Cell-Derived Exosomes in Promoting Diabetic Foot Ulcer Healing: A Meta-Analysis of Preclinical Animal Studies.
Meta-analysis on Diabetic Foot, Chronic Wound, published in J Diabetes Res (2026) — summary generated from the PubMed abstract.
- 2026
J Diabetes Res - Level ASystematic ReviewEurope PMC
The Role of Exosome-miRNA as Biomarkers of Alzheimer's Disease: A Systematic Review of Case-Control and Longitudinal Studies
Systematic Review with a reported sample of 3046 on Neuroinflammation, published in Actas Esp Psiquiatr (2026) — summary generated from the PubMed abstract.
- 2026
- n = 3046
Actas Esp Psiquiatr - Level AMeta-analysisEurope PMC
Exosome-based therapy for epilepsy: a systematic review and meta-analysis of preclinical studies
Meta-analysis on Neuroinflammation, published in Front Neurosci (2026) — summary generated from the PubMed abstract.
- 2026
Front Neurosci - Level AMeta-analysisEurope PMC
Efficacy of stem cell therapy for achilles tendon rupture: a systematic review and meta-analysis based on animal studies
Meta-analysis on Tendon Injury, published in Front Bioeng Biotechnol (2026) — summary generated from the PubMed abstract.
- 2026
Front Bioeng Biotechnol