Stem-Cell-Assisted Lipotransfer and Platelet-Rich Plasma in Breast Reconstruction: A Literature Review.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Autologous fat transplantation to the breast, a minimal invasive technique, has significantly expanded in aesthetic and reconstructive surgery over the past two decades. Initially used for lumpectomy defects or correcting contour deformities post-breast reconstruction, it is now also performed as a stand-alone technique for primary breast augmentation or as a complementary method to implant-based augmentation. However, this surgical technique is associated with a high absorption rate. The use of fat grafts for breast augmentation remains controversial due to concerns about its safety, efficacy, and impact on breast cancer. Methods This review examines the literature on cell-assisted lipotransfer (CAL) and PRP-assisted lipotransfer, comparing fat graft survival, complication rates, and oncological safety with conventional autologous lipotransfer. Results CAL and PRP-assisted lipotransfer techniques demonstrate improved fat graft retention and reduced complications compared to conventional methods. Several studies report a potential reduction in the absorption rate of fat grafts with improvements in aesthetic outcomes. Conclusions While CAL and PRP-assisted lipotransfer have shown promising results in enhancing fat graft survival and reducing complications, there are still concerns about their oncological safety. No level assigned This journal requires that authors ass

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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