Stem Cell-Assisted Lipotransfer and the Private Breast Surgery Market.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Over the last decade autologous fat from subcutaneous tissue has been used by plastic surgeons for face volumization. It has also been used with growing frequency for aesthetic breast enhancement. Currently, experts in this field are becoming increasingly aware of the potential of fat for breast reconstruction. However, the safety of fat transfers to post-mastectomy defects has been called into question in recent debates due to the, albeit rare, observations of their possible influence on local cancer recurrence. The majority of concerned opinions are based on the safety of fat supplementation with additional amounts of adipose mesenchymal and stem cells. In experimental conditions, these cells were shown to create pathophysiological microenvironments and promote neoplastic transitions. This raises the question as to whether breast reconstruction with enriched fat is sufficiently safe to be performed without scientific justification and whether the present legal regulations are sufficient to guarantee patient safety in small facilities. In a number of circumstances, patients who have undergone treatment in profit-oriented offices, outside the system of oncological or surgical centers, might have been left without any long-term cancer surveillance. Valid opinions have also been expressed on the grounds of the ethical doubts concerning the advertising used by cosmetic practitione

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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