Stem cell transplantation in head and neck oncology: Integrating oncologic treatment and maxillofacial reconstruction

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Head and neck malignancies are aggressive, have complex anatomical placements, and require extensive surgical intervention for functional and cosmetic reasons. Recent advances in stem cell biology have expanded our understanding of their activities beyond oncogenic pathways to encompass tissue repair and regeneration. Mesenchymal and pluripotent stem cells have been studied for their immunomodulatory, microenvironmental, and bone and soft-tissue regeneration abilities following oncologic resection. Stem cells can connect oncologic treatment with reconstructive surgery, as shown in this narrative assessment of recent translational and regenerative advances in head and neck oncology. Autologous and allogeneic stem cell-based approaches, often combined with bioengineered scaffolds, have been shown to improve vascularization and functional restoration in complex craniofacial structures. Despite these promising advances, worries about tumor recurrence, stem cell plasticity, and the carcinogenic dangers of introducing stem cell-derived or growth-factor-enriched materials into previously treated or irradiated areas persist. In addition, regulatory, ethical, and scientific barriers prevent the widespread use of stem cell-based therapies in clinical oncology. Stem cell-centered research can transform head and neck cancer treatment from survival-focused to holistic oncological and functi

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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