SVF
Level A· Stronger Clinical EvidenceSystematic Review

Stromal Vascular Fraction in Bone Healing: A Systematic Review of Clinical Evidence and Potential Implications in Skull Base Reconstruction and Cranioplasty.

Ferreira MY., Campos Cardoso LJ., Pereira AL., Ribeiro FV., Nascimento FGO., Cheidde L.

Systematic Review with a reported sample of 214 on Chronic Wound, Immune Modulation, published in J Craniofac Surg (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Systematic Review
Journal
J Craniofac Surg (2026)
Country
United States
Reported sample size
214
PMID
41711644
DOI
10.1097/SCS.0000000000012356

Abstract (original English)

Bone healing following pathology or surgery is a complex, multiphase process involving coordinated cellular and molecular activities. Various stimulation strategies have been used to enhance bone repair. Recently, stromal vascular fraction (SVF)-a heterogeneous, adipose-derived cell mixture containing pericytes, smooth muscle cells, and adipose-derived stem cells with regenerative, immunomodulatory, and angiogenic properties-has been explored in clinical settings to promote accelerated bone regeneration. Following the PRISMA guidelines, a systematic search was conducted in PubMed, Embase, and Web of Science. Eligible studies were English-language clinical investigations involving patients with bone defects treated with SVF, either alone or combined with other interventions, reporting outcomes related to bone repair. Ten clinical studies (5 case reports, 4 prospective cohorts, and one randomized clinical trial) involving 214 patients (46.3% male) were included. Radiologic and histologic assessments consistently showed enhanced bone regeneration in SVF-treated sites, including increased ossification, bone volume, mineral content, and defect closure. Quantitative comparisons, where available, favored SVF in bone dimensions, fusion rates, and implant success. Stromal vascular fraction therapy was well tolerated, with no serious adverse events and only minor, self-limited complicati

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
HumansBone RegenerationPlastic Surgery ProceduresWound HealingStromal Vascular FractionSkullAdipose Tissue
Chronic WoundImmune Modulation
View on PubMedDOI

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