Study on Age-Related Facial Fat Changes Using 3D MRI and a Novel Algorithm

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Age-related changes in facial and cervical fat distribution play a critical role in aesthetic appearance; yet, quantitative evidence remains limited. Objectives This study aimed to quantitatively characterize regional fat distribution patterns of the neck and face across different age groups using advanced imaging, and to examine the relationships between age, body mass index (BMI), and fat distribution. Methods A cross-sectional study was conducted in 47 healthy female participants aged 18-65 years. High-resolution 3-dimensional magnetic resonance imaging (3D MRI) was used to measure fat thickness and volume across predefined anatomical compartments. Results Neck fat thickness and volume showed significant positive correlations with both age and BMI, with the greatest increases observed in midlife. Facial fat demonstrated region-specific remodeling rather than uniform descent. Buccal fat pad and nasolabial fold volumes significantly decreased with age, whereas upper facial superficial fat remained stable. Infraorbital fat volume and thickness exhibited a distinct age-related increasing trend, particularly between young and middle-aged groups. Conclusions This study reveals potential heterogeneous age-related changes in facial and cervical fat distribution through quantitative imaging analysis. Our findings suggest that distinct fat compartments may age at different

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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