Successful Treatment of Female Pattern Hair Loss with Injection of Autologous Adipose-derived Adult Stem Cells: A Controlled Clinical, Trichoscopic, and Immunohistochemical Trial.

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Hair follicles undergo growth, regression, and quiescence. It is suspected that adipocytes secrete factors that promote the activation of follicular dermal papilla cells, increase migration and proliferation in vitro , and increase the conversion of hair follicles from the telogen to anagen phase in vivo . Objectives To evaluate the efficacy of adipose derived stem cells (ADSCs) injection for the treatment of female pattern hair loss (FPHL). Patients and methods This prospective randomized controlled trial included 33 patients divided into three groups according to Sinclair classification. ADSCs were extracted from autologous fat obtained from the lipoaspirate, cultured, and injected into the frontoparietal scalp. The patients were assessed clinically, trichoscopically, histopathologically, and immunohistochemically for hair cycle markers. Results At weeks 12 and 24, there was an improvement in hair thickness and count, and an increased number of hairs per follicular unit. Histopathological and immunohistochemical assessments at week 12 showed a decrease in perifollicular inflammation, an increase in the hair cycle stimulatory marker (follistatin), and a decrease in hair cycle suppressor (DKK-1) immunostaining. Conclusion The use of ADSCs in subjects with FPHL included in this study showed increased hair density and thickness, improved perifollicular inflammation, an

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.