Superior Retention of Aged Fat Graft by Supplementing Young Adipose-Derived Stromal Cells in a Murine Model.

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

In 2021, a meta-analysis showed that fat graft retention varied from 26% to 83%. In a retrospective study including patients with Parry-Romberg syndrome, the younger age group had higher satisfaction scores (3.8 versus 3.0) after fat grafting. Cell-assisted lipotransfer could be an alternative to overcome the instability of volume loss; however, no study has investigated its effect on older recipients. In an in vitro study, adipose-derived stromal cells (ASCs) from aged and young (52 and 8 weeks old) DsRed B6 mice were characterized by proliferation rates as percentages of Ki-67-positive cells. In addition, 68-week-old wild-type B6 mice received 150 µL of green fluorescent protein fat (from 69-week-old B6 mice) mixed with saline or 3 × 10 5 aged or young DsRed ASCs (N, A, and Y groups, respectively) on the scalp ( n = 6/group). After 8 weeks, graft volumes were evaluated using microcomputed tomography. Vessel densities were tracked by percentages of CD31 using immunofluorescence staining. Young ASCs showed higher proliferation than aged ASCs (47.1% and 26.2%, respectively; P < 0.05). The Y group showed the highest graft retention (median: N, 41.0%; A, 52.2%; Y, 65.2%; P < 0.05) and percentage of blood vessels (median: N, 27.7%; A, 43.5%; Y, 54.7%; P < 0.05) among the 3 groups. Cell-assisted lipotransfer is effective with older recipients. Higher effect was observed by supplemen

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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