Synergistic Enhancement of Therapeutic Efficacy in Acute Myocardial Infarction via Nanoflower-Like Mn 3 O 4 Nanozymes in Coordination with Adipose-Derived Stem Cell Transplantation.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Acute myocardial infarction (AMI) is a leading cause of mortality worldwide. Adipose-derived stem cell (ADSC) transplantation presents a promising therapeutic approach for AMI; however, the harsh microenvironment of the infarcted myocardium, characterized by hypoxia and oxidative stress, limits the survival and efficacy of ADSCs. Nanozymes (NZs), which have robust anti-oxidative enzyme-mimicking activities, have demonstrated potential in combating oxidative stress and improving cell viability. Mn3O4 NZs (Mn-Nzs), which have nanoflower-like structures were synthesized and their structure and multi-enzyme mimetic activities (superoxide dismutase, catalase, and glutathione peroxidase) were characterized. Blood biochemical parameters were measured in the heart, liver, spleen, lungs and kidneys of the rats, followed by hematoxylin and eosin (HE) staining. The impact of Mn3O4 NZs on reactive oxygen species (ROS) levels, and viability of ADSCs under oxidative stress was assessed in vitro. In vivo studies were conducted using a rat AMI model to evaluate the therapeutic efficacy of ADSC transplantation, in conjunction with Mn3O4 treatment. In addition, proteomic analysis was performed to elucidate the mechanisms of action underlying the therapeutic effects. Mn 3 O 4 NZs exhibited multi-enzyme mimetic activities, including superoxide dismutase, catalase, and glutathione peroxidase, reduc

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.