Synergistic Innovative Therapies in Dermatology: Integrating Platelet Derivatives, Biomaterials, and Exogenous Bioactive Substances for Enhancing Skin Repair and Regeneration

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background The treatment of dermatological diseases has evolved significantly with the advent of advanced therapeutic strategies involving platelet-rich products. These products are rich in morphogens, growth factors, and proteins that play a crucial role in tissue regeneration and wound healing. Their combination with different biomaterials has been engineered to enhance the biomaterials' safety and performance in the context of tissue healing. Objective This narrative review aims to explore the current evidence on the biological mechanisms, efficacy, and clinical applications of these combined therapies. Furthermore, we examine the potential advantages of synergistic effects and the challenges associated with optimizing treatment protocols. Methods Relevant literature was retrieved through a structured search strategy implemented across PubMed, Scopus, and Google Scholar databases. Studies included investigated co-administration of platelet-rich products with other agents in topical, injectable, or composite formulations for dermatological conditions with no restriction regarding publication date. Results The review summarizes in vitro and in vivo biological effects of various biopolymers and active substances combined with platelet-rich products, highlighting diverse application strategies and their effectiveness across dermatological contexts. Conclusion Adding platelet-ric

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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