Systemic Administration of Adipose-Derived Stem Cells Immediately after Radiotherapy to Prevent Development of Late Radiation-Induced Damage.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Radiotherapy is a well-established cancer treatment, but its detrimental effects on normal tissue have been underestimated. Late radiation-induced tissue damage leads to dysfunction, such as loss of elasticity and delayed wound healing, which negatively affect the prognosis and quality of life of cancer survivors. The authors' previous research demonstrated that local prophylactic administration of adipose-derived stem cells (ASCs) immediately after irradiation could prevent late radiation-related disorders. This study explored the effects of systemic administration of ASCs for future clinical applications. Methods Nude mice were irradiated on their dorsal skin (40 Gy total: 2 Gy × 20, simulating clinical radiotherapy). Human ASCs were administered systemically (through intravenous or intraperitoneal injection, once or twice). Control groups included a nonirradiated group and a vehicle-treated radiotherapy group. After 6 months, full-thickness skin wounds were created on the mice's dorsal skin and observed for 28 days. The wound-healing process was assessed, and tissue samples were analyzed using immunohistochemistry. Results Radiotherapy caused subcutaneous fat atrophy and fibrosis at 6 months, which was effectively prevented in the ASC-treated groups. Wound healing was faster in the ASC-treated groups than in the vehicle-treated groups, although not as fast as in t

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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