SVF
Level D· Preclinical EvidenceAnimal Study

Systemic Administration of Adipose-Derived Stem Cells Immediately after Radiotherapy to Prevent Development of Late Radiation-Induced Damage.

Toyohara Y., Sowa Y., Saito N., Shirado T., Zhang B., Hyun S.

Animal Study on Chronic Wound, published in Plast Reconstr Surg (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Animal Study
Journal
Plast Reconstr Surg (2026)
Country
United States
Reported sample size
—
PMID
40957110
DOI
10.1097/PRS.0000000000012449

Abstract (original English)

Radiotherapy is a well-established cancer treatment, but its detrimental effects on normal tissue have been underestimated. Late radiation-induced tissue damage leads to dysfunction, such as loss of elasticity and delayed wound healing, which negatively affect the prognosis and quality of life of cancer survivors. The authors' previous research demonstrated that local prophylactic administration of adipose-derived stem cells (ASCs) immediately after irradiation could prevent late radiation-related disorders. This study explored the effects of systemic administration of ASCs for future clinical applications. Nude mice were irradiated on their dorsal skin (40 Gy total: 2 Gy × 20, simulating clinical radiotherapy). Human ASCs were administered systemically (through intravenous or intraperitoneal injection, once or twice). Control groups included a nonirradiated group and a vehicle-treated radiotherapy group. After 6 months, full-thickness skin wounds were created on the mice's dorsal skin and observed for 28 days. The wound-healing process was assessed, and tissue samples were analyzed using immunohistochemistry. Radiotherapy caused subcutaneous fat atrophy and fibrosis at 6 months, which was effectively prevented in the ASC-treated groups. Wound healing was faster in the ASC-treated groups than in the vehicle-treated groups, although not as fast as in the no-radiotherapy group. A

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence comes from animal or laboratory studies and has not been confirmed in humans.

How we grade evidence
AnimalsMiceMice, NudeHumansWound HealingSkinStem Cell TransplantationAdipose TissueRadiation Injuries, ExperimentalRadiation Injuries
Systemic / IVChronic Wound
View on PubMedDOI

Related research