Therapeutic Potential and Comparison of the Effects of Mummy on Mesenchymal Stem Cells Derived from Wharton's Jelly and Adipose Tissue Cultured with Human Fibroblasts.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background: The wound healing process is a complex physiological mechanism that plays a crucial role in medical treatment. The slow healing rates and scar formation associated with many conventional therapies have prompted researchers to explore novel and more effective therapeutic options. This study investigates the effects of Mummy material, Wharton Jelly Stem Cells (WJSCs), and Adipose Stem Cells (ASCs) on the migration and proliferation of fibroblasts. Materials and Methods: This study demonstrated that fibroblast cells could successfully adhere to three-dimensional (3D) scaffolds within the specified microenvironment. ASCs were isolated from human adipose tissue, while WJSCs were obtained from women undergoing cesarean sections. We assessed the proliferation rate, migration, expression of fibronectin, collagen types I and III, and cell adhesion on polycaprolactone (PCL) scaffolds in the presence of Mummy material. Results: The findings highlighted the critical role of mummy material, ASCs, and WJSCs in promoting fibroblast migration and proliferation. The presence of these components significantly enhanced the expression of fibronectin (FN1) and collagen types I and III. Furthermore, the mummy material stimulated the proliferation of ASCs and WJSCs seeded on PCL scaffolds. Collectively, these results establish a valuable in vitro model for investigating wound healing mech

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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