Therapeutic potential of exosomes in periodontal regeneration: Immunomodulatory and tissue-repair mechanisms

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Periodontitis, a chronic inflammatory disease leading to irreversible tissue destruction, is a highly prevalent oral disease. The clinical management of periodontitis is challenging because conventional treatments like mechanical debridement and antibiotic therapy lack sufficient regenerative efficacy to achieve functional periodontal restoration. In recent years, exosomes have received widespread attention as cell-free therapeutic agents for periodontal tissue regeneration. This article reviews the dual role of exosomes in modulating immune response and promoting tissue repair, and briefly describes the exosome delivery systems studied so far. The aim of this review is to emphasize the important position occupied by cell-derived exosomes in the treatment of periodontitis as well as the main mechanisms, and to explore novel targets for the treatment of periodontitis.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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