Therapeutic Potential of Mesenchymal Stem Cells in Psoriasis

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Psoriasis is a chronic immune-mediated disease mainly affecting the skin with different clinical manifestations. As patients with psoriasis may also suffer from psoriatic arthritis and the skin lesions of psoriasis are disfiguring, their quality of life is often impaired. Many environmental and genetic factors have been implicated in psoriasis development. Currently, there is no cure for the disease and long-term drug treatment is usually necessary, especially in moderate to severe cases. Mesenchymal stem cells (MSCs) are popular candidates for cell-based treatment in many immune-mediated diseases due to their ability to secrete a wide array of cytokines and growth factors and their immunomodulatory properties. MSCs from various sources administered via different routes have been shown to ameliorate psoriasis. This review gives an overview of psoriasis and MSCs and examine preclinical and clinical studies concerning the application of MSCs in the treatment of psoriasis, as well as consolidate major findings in this area of research.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.