Therapeutic potential of stem cell-derived exosomes in hair regeneration: A systematic review

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Exosome-based therapies represent a promising approach for hair regeneration. Unlike conventional treatments such as minoxidil and finasteride, exosomes deliver bioactive cargo that can stimulate dermal papilla cells, enhance angiogenesis, and modulate inflammatory pathways. However, variability in exosome sources, isolation techniques, and dosing protocols limits their clinical translation. Aim To synthesize findings from in vitro , preclinical and clinical studies, and to evaluate the efficacy, mechanisms, and challenges associated with exosome-based hair restoration therapies. Methods A literature search was conducted using multiple databases (PubMed/Medline, Embase, Scopus, and Web of Science) employing terms for exosomes and hair regeneration for articles published in English to February 2025, following Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Results A total of 27 studies (three in vitro , three pre-clinical, 18 with both in vitro and pre-clinical component and three clinical) met the pre-defined search and inclusion criteria and were included in this review. Conclusion Exosome-based therapies hold immense promise for hair regeneration by leveraging their ability to modulate key signaling pathways and enhance hair follicle regeneration. While in vitro and preclinical studies demonstrate consistent efficacy across diverse ex

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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