Use of exosomes as adjuvant therapy in the reconstruction of traumatic eyelid wounds: A case report.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Traumatic eyelid wounds with tissue loss pose a reconstructive challenge due to the risk of inflammation-driven fibrosis and functional impairment. Adipose-derived stem cell-derived exosomes have demonstrated regenerative and antifibrotic effects in cutaneous wound-healing models. We report a case of high-energy periocular trauma in which standard oculoplastic reconstruction was supplemented with staged topical and microneedling-assisted exosome therapy. Accelerated epithelialization, favorable scar modulation, and preservation of eyelid contour and function were observed without adverse events. This case supports the feasibility of exosome-based therapy as an adjunct in complex eyelid wound reconstruction.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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