The Use of Extracellular Vesicles as a Promising Therapeutic Approach for Pulmonary Diseases

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background and aims Pulmonary disorders significantly impact worldwide healthcare, highlighting the necessity for enhanced diagnostic and treatment approaches. This narrative review seeks to investigate the potential of extracellular vesicles (EVs) as an innovative therapeutic strategy for diverse pulmonary disorders. Methods This review synthesizes existing data about the function of extracellular vesicles (EVs) in pulmonary health and pathology, emphasizing their modes of action, including the transfer of proteins, nucleic acids, and lipids for intercellular communication. It also examines the implications of EVs in targeted medication delivery, immunomodulation, and tissue regeneration. Results EVs, including microvesicles and exosomes, have demonstrated promise in treating respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis, and acute respiratory distress syndrome (ARDS). Additionally, EVs may serve as valuable biomarkers for early disease detection, prognosis, and monitoring. However, challenges remain regarding the standardization of EV isolation methods and characterization protocols to ensure safety and clinical applicability. Conclusion In summary, extracellular vesicles hold potential for transforming the management of pulmonary diseases by providing insights into pathophysiology, enabling early diagnosis, and facilita

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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