Valorization of <i>Channa striatus</i> waste skin for developing marine collagen peptide based hydrogels for potential wound dressings

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

This study focuses on the extraction and characterization of a bioactive collagen peptide from waste skin of a local species of fish, the Channa striatus /snakehead/'shol' fish. The extracted peptides were characterized and optimized for the formulation of chitosan/PVA/collagen peptide (CP) hydrogel which has not been done previously. The facile extraction process involved using alkali, butanol, and protease for non-collagenous protein and fat removal, and enzymatic hydrolysis respectively. Hydrogels were formulated using a non-toxic freeze-thaw technique with multiple combinations of chitosan, PVA, and collagen peptide and characterized with SEM, FTIR, swelling ratio, gel content, porosity, evaporation rate, and antibacterial and anti-inflammatory activity. The FTIR fingerprint of the collagen peptide confirmed the presence of characteristic amide bonds. The SEM image of the collagen peptide reveals an open morphological structure suggesting that enzymatic hydrolysis could produce lower molecular weight collagen peptide. The collagen peptide retained 53.31% total protein in which essential amino acids - 27.3% glycine, 8.74% arginine, and 14.11% proline - were present. Antioxidant properties - DPPH, hydroxide, and superoxide radical scavenging activity - demonstrated a linear correlation with collagen peptide concentration. The swelling ratio, a crucial structural property for

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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