SVF
Level D· Preclinical EvidenceAnimal Study

Verification of renal tissue regeneration using human perinephric fat-derived collagen sheet in a partially nephrectomized animal model.

Kim BS., Lee EH., Yoon BH., Jeon M., Kang JK., Chung JW.

Animal Study on Chronic Kidney Disease, Scar, Chronic Inflammation, published in J Biomater Appl (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Animal Study
Journal
J Biomater Appl (2026)
Country
England
Reported sample size
—
PMID
41247038
DOI
10.1177/08853282251399548

Abstract (original English)

Chronic kidney disease (CKD), a global health issue, affects approximately 10% of the population. However, limited treatment options, such as dialysis or transplantation, have significant drawbacks. Therefore, this study aims to investigate the potential of a collagen sheet derived from human perirenal adipose tissue for kidney regeneration. Collagen sheets were derived from discarded perirenal adipose tissues and implanted into partially nephrectomized mice. The right kidneys were completely removed, and 2 mm of the upper and lower poles of the left kidneys were resected. A collagen sheet measuring 1 × 1 × 3 mm 3 was implanted in the mid-pole of the left kidney following partial resection of renal parenchyme. Renal function, inflammation, and tissue regeneration were evaluated using serum analysis, PCR, histological staining, and immunohistochemistry to assess structural and functional improvements. The collagen sheet reduced pro-inflammatory markers, minimized fibrosis, and restored renal function indicators such as BUN and cystatin C, though creatinine levels remained unchanged. Regenerative markers, including PAX2 and Wt1, were significantly elevated, indicating enhanced tissue repair and structural recovery. The perirenal adipose tissue-derived collagen sheet demonstrated anti-inflammatory effects and promoted renal tissue regeneration. These findings suggest its potential

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence comes from animal or laboratory studies and has not been confirmed in humans.

How we grade evidence
AnimalsCollagenHumansRegenerationAdipose TissueKidneyMiceNephrectomyMaleDisease Models, Animal
Systemic / IVChronic Kidney DiseaseScarChronic Inflammation
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