What are the best clinical management strategies for cardiomyopathy? an umbrella review of systematic reviews and meta-analyses

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background The aim of this study is to summarize and evaluate the quality of evidence regarding the effectiveness and safety of different interventions for patients with cardiomyopathy, based on published meta-analyses through an umbrella review. Materials and methods The literature was searched via PubMed, Embase, Web of Science, and the Cochrane Library. Two reviewers evaluated the methodological quality of the included articles using the AMSTAR score. In addition, according to the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE), evidence of each outcome was evaluated and graded as "high," "moderate," "low," or "very low" quality for drawing conclusions. Additionally, each outcome was classified into four categories (classes I-IV and nonsignificant). Results High-quality evidence suggested that for patients with cardiomyopathy, stem cell treatment could significantly improve left ventricular ejection fraction (LVEF), left ventricular ejection volume, 6-min walk distance (6-MWD), and New York Heart Association (NYHA) functional classification. High-quality evidence also suggested that for patients with dilated cardiomyopathy (DCM), adding traditional Chinese medicines (TCMs) such as Qili Qiangxin capsule (QQC), Shenmai injection (SMI), Zhigancao, and Shengmai to conventional Western medical treatment could significantly improve clinical effects, inc

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.