Level D· Preclinical EvidenceAnimal Study

Adipocyte-derived amino acid storage proteins are required for germline stem cell maintenance in adult Drosophila females.

Zike AB., Hazen MO., Abel MG., Goldstone EB., Eisman RC., Weaver LN.

Animal Study on Hair & Scalp, published in Dev Biol (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type: Animal Study
Journal: Dev Biol (2026)
Country: United States
Reported sample size: —
PMID: 41825648
DOI: 10.1016/j.ydbio.2026.03.004

Abstract (original English)

Tissue homeostasis is dependent on precise coordination between endocrine organs in response to changes in organism physiology. Secreted circulating factors from adipocytes regulate the behavior of stem cell lineages in peripheral tissues in multiple organisms. In addition to their endocrine roles, Drosophila adipocytes store and secrete amino acid storage proteins throughout development. During the larval feeding period, adipocytes secrete storage proteins into the hemolymph, which are reabsorbed by the adipose tissue during metamorphosis to control adult organ size and fertility. Despite the known functions for storage proteins during the larval stages, their requirement during Drosophila adulthood and reproduction are uncharacterized. We discover that adipocyte-specific knockdown of the storage proteins Larval serum protein 1 (Lsp1) α/β/γ and Larval serum protein 2 (Lsp2) results in a decrease in germline stem cell (GSC) maintenance. We further reveal that decreased GSC number is due to downregulation of Target of Rapamycin (TOR) signaling in GSCs, suggesting compromised amino acid sensing directly in GSCs. We also find that the proteins that mediate storage protein adipocyte reabsorption, Fat body protein 1 (Fbp1) and Fat body protein 2 (Fbp2), are expressed in ovarian follicle cells. Intriguingly, Fbp1 nor Fbp2 appear to be required in follicle cells for GSC maintenance, s

What this study does not prove

• This study does not prove SVF is an approved treatment or a replacement for standard care.
• This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence comes from animal or laboratory studies and has not been confirmed in humans.

How we grade evidence

AnimalsFemaleDrosophila ProteinsAdipocytesStem CellsAmino AcidsDrosophila melanogasterSignal TransductionGerm CellsOvarian Follicle

Hair & Scalp

View on PubMed DOI

Adipocyte-derived amino acid storage proteins are required for germline stem cell maintenance in adult Drosophila females.

Abstract (original English)

What this study does not prove

Evidence level

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