Autologous minimally manipulated adipose-derived stromal vascular fraction in knee osteoarthritis: Lasting symptom relief and imaging evidence from a 12-month prospective study.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Purpose To evaluate the safety and efficacy of intra-articular autologous transplantation of adipose-derived connective tissue micrografts rich in stromal vascular fraction (CTM-SVF), obtained using an enzyme-free system (Hy-Tissue® SVF) for knee osteoarthritis (OA). Methods Thirty patients (mean age of 53.3 ± 6.4 years) with Kellgren-Lawrence grade I to III knee OA received a single intra-articular injection of autologous CTM-SVF prepared with the Hy-Tissue SVF concentration system. Follow-ups were set at 3-, 6- and 12-month postinjection. Outcome measures included knee injury and osteoarthritis outcome score (KOOS), pain relief (NRS-11), quality of life (EQ-5D index), magnetic resonance imaging (MRI) scans (whole-organ magnetic resonance imaging score-WORMS, T2 mapping), OA serum biomarkers, safety and local tolerability. Results One patient discontinued prematurely. KOOS improved significantly, with the highest mean score (68.7 ± 14.9) at 3 months and the majority of patients achieving a ≥ 9-point increase from baseline. Results were maintained through 12 months. NRS-11 and EQ-5D also improved through 12 months, with more than 80% of patients meeting the NRS-11 MCID at every timepoint. EQ-VAS, however, showed only a modest responder rate (10%). MRI revealed improvements in T2 relaxation times, while OA serum biomarkers (evaluated at 3 months postinjection) indicated a signif

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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