Autologous Versus Allogeneic Adipose-Derived Mesenchymal Stem Cell Therapy for Knee Osteoarthritis: A Systematic Review, Pairwise and Network Meta-Analysis of Randomized Controlled Trials.

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Knee osteoarthritis (OA) is a degenerative joint disorder with limited non-surgical treatment options. Adipose-derived mesenchymal stem cell (AD-MSC) therapy has emerged as a promising regenerative approach; however, the comparative efficacy and safety of autologous versus allogeneic AD-MSCs remain unclear. This systematic review and network meta-analysis (NMA) evaluated the effectiveness and safety of intra-articular AD-MSCs in adults with Kellgren-Lawrence Grade II-IV knee OA. A comprehensive search identified eight randomized controlled trials that compared high-dose autologous, high-dose allogeneic, and low-dose allogeneic AD-MSCs to placebo or standard care interventions, such as hyaluronic acid, corticosteroids, or physical therapy. The primary outcomes were pain relief, assessed by the Visual Analog Scale (VAS), and functional improvement, measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), at three, six, and 12 months. Treatment rankings were determined using Surface Under the Cumulative Ranking (SUCRA) probabilities. High-dose autologous AD-MSCs ranked highest for pain relief at three, six, and 12 months (VAS SUCRA: 75.99%, 82.27%, 81.65%), while high-dose allogeneic AD-MSCs ranked highest for functional improvement at six and 12 months (WOMAC SUCRA: 74.6%, 71.71%). Low-dose allogeneic AD-MSCs consistently ranked lowest for both outc

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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