Clinical Outcomes of Adipose-Derived Cell-Based Therapies Versus Platelet-Rich Plasma in Knee Osteoarthritis: A Systematic Review.

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Knee osteoarthritis (OA) is a common degenerative joint condition for which current treatments primarily provide symptom control without restoring cartilage. Biologic injectables such as platelet-rich plasma (PRP) and adipose-derived cellular preparations have gained interest as potential disease-modifying options. This review compares the current clinical evidence regarding their relative effectiveness. Methods Following PRISMA 2020 guidelines, PubMed, Scopus, Cochrane Library, Europe PMC, and CNKI were searched. Eligible studies were level 1-2 clinical trials directly comparing PRP with adipose-derived cell-based therapies in knee OA. Pain, function, quality of life, sports activity, and complications were assessed. Quality was evaluated using MINORS. Results Three studies (two hundred forty-one knees) were included, all high quality (MINORS 19-24). Both PRP and adipose-derived cell-based therapies significantly improved pain, function, and quality of life with no reported complications. Two studies showed no difference between PRP and microfragmented or autologous adipose tissue (MFAT/AAT) at 6-12 months. One study found culture-expanded adipose-derived stem cells (ADSCs) provided greater improvements in pain (WOMAC, VAS), stiffness, and several SF-36 domains compared with PRP at 6 months. Conclusion PRP and adipose-derived cell-based therapies are safe and effect

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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