SVF
Level C· Early Human ResearchCase Report / Series

Effect of autologous adipose-derived mesenchymal stem cell therapy in combination with autologous platelet-rich plasma in the treatment of elbow tendinopathy.

Freitag J., Shah K., Wickham J., Tenen A.

Case Report / Series on Tendon Injury, Chronic Inflammation, published in BMJ Case Rep (2020) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Case Report / Series
Journal
BMJ Case Rep (2020)
Country
England
Reported sample size
—
PMID
32606116
DOI
10.1136/bcr-2020-234592

Abstract (original English)

Tendinopathy is a common condition of both the athletic and general population and can be associated with significant pain and disability. The ability of mesenchymal stem cells (MSCs) to differentiate along a mesodermal cell lineage, including tenocytes, and secrete various bioactive regenerative and anti-inflammatory molecules has seen them considered as a future reparative therapy for tendinopathy. Preclinical trials with MSCs have shown promising positive functional and structural outcomes in several connective tissue related conditions. A 52-year-old male professional masters golfer presents with a clinical history of common extensor origin tendinopathy of the elbow. Subsequent formal ultrasound showed evidence of a large intrasubstance tear. The patient underwent intratendinous autologous adipose-derived MSC therapy in combination with autologous platelet-rich plasma. Following treatment, the patient reported progressive improvement as measured by the validated Numeric Pain Rating Scale and Patient-Rated Tennis Elbow Evaluation score. Repeat imaging showed successful regeneration of tendon-like tissue.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • Without an adequate control group, treatment effects cannot be separated from other factors.

Evidence level

Early human evidence such as case series or small samples, often without a control group.

How we grade evidence
Athletic InjuriesElbow JointElbow TendinopathyGolfHumansMaleMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMiddle AgedPain Measurement
Arm & ElbowTendon InjuryChronic Inflammation
View on PubMedDOI

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