Efficacy and safety of micro-fragmented adipose tissue combined with knee arthroscopy in the treatment of knee osteoarthritis: a systematic review.

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Knee osteoarthritis (KOA) is a prevalent degenerative joint disease that significantly impairs quality of life, particularly in the elderly and increasingly in younger populations due to factors like obesity and joint injuries. Traditional treatments often fall short, leading to a growing interest in regenerative therapies. Micro-fragmented adipose tissue (MFAT), rich in mesenchymal stem cells and growth factors, has emerged as a promising biological material for cartilage repair and inflammation suppression. When combined with knee arthroscopy, a minimally invasive surgical technique, MFAT offers a novel approach to treating KOA by enabling precise delivery and enhanced therapeutic outcomes. This systematic review evaluates the efficacy and safety of MFAT combined with knee arthroscopy for KOA treatment. Following PRISMA and AMSTAR guidelines, a comprehensive search was conducted across PubMed, Cochrane Library, EMBASE, and Web of Science databases from inception until February 2025. Studies were included if they involved MFAT injection via knee arthroscopy in patients aged ≥18 years with KOA, with a minimum follow-up of 6 months. Data extraction and quality assessment were performed independently by two reviewers, with disagreements resolved by a third. The Cochrane Risk of Bias Tool and MINORS criteria were used to assess study quality. Six studies (2 RCTs and 4 retrospectiv

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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