Efficacy of Stem Cell-Derived Exosomes in Promoting Diabetic Foot Ulcer Healing: A Meta-Analysis of Preclinical Animal Studies.

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The objective of the study is to systematically evaluate the efficacy and mechanisms of action of stem cell-derived exosomes from various sources (including adipose tissue [AD-MSCs] and bone marrow [BM-MSCs]) in treating diabetic foot ulcers (DFUs) based on preclinical evidence. A computerized search was performed across multiple databases including PubMed, CBM, Web of Science, Embase, Wanfang, CNKI, the Cochrane Library, and VIP. The search period covered the period from their inception through December 2024. The search is aimed at identifying all relevant randomized controlled trials (RCTs) using animal models of DFU. Ten studies involving 239 animals were included in the final meta-analysis. Data synthesis and statistical analysis were performed using RevMan 5.4. The risk of bias was assessed with SYRCLE's tool. The pooled results demonstrated that stem cell-derived exosomes significantly promoted wound healing, evidenced by increased wound healing rates on Day 7 (SMD = 8.41, 95% CI: 4.06-12.75, p < 0.001; I 2 = 91%) and Day 14 (SMD = 4.89, 95% CI: 3.63-6.14, p < 0.001; I 2 = 0%). Furthermore, exosome treatment enhanced neovascularization density (SMD = 7.78, 95% CI: 6.04-9.52, p < 0.001), collagen deposition (SMD = 8.59, 95% CI: 2.16-15.03, p < 0.05), and reduced levels of inflammatory markers (TNF-α and CD86). Subgroup analyses revealed that the administration dose was a m

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.