Intraarticular injection of the stromal vascular fraction for the treatment of knee osteoarthritis a prospective randomized controlled clinical trial.

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Currently, conservative treatment for knee osteoarthritis (KOA) has limited efficacy, and autologous adipose-derived stromal vascular fraction (SVF) knee injections, a novel treatment approach, are receiving widespread attention. Our study aimed to explore the efficacy and safety of SVF treatment for KOA patients. This randomized controlled trial sought to assess the efficacy and safety of intra-articular SVF injections for the treatment of KOA, both as an independent intervention and in conjunction with conventional rehabilitation. Sixty-six KOA subjects were randomly divided into three groups: (1) the SVF group received a single SVF intra-articular knee injection; (2) the control group received conventional rehabilitation treatment (muscle strength training, interferential therapy, and manual therapy, 5 times a week for a total of 4 weeks); and (3) the combination therapy group received a single SVF intra-articular knee injection followed by conventional rehabilitation treatment. Outcomes were assessed during a 12-month follow-up period, with outcome measures including the visual analog scale for pain; the Western Ontario and McMaster Universities Osteoarthritis Index for pain, stiffness, and function; range of motion (ROM); and the occurrence of complications. A total of 62 patients completed the follow-up. There were no significant baseline differences among the groups. The

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.