Knee adipose tissue: from its implication in osteoarthritis to its supposed role in tissue engineering.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Knee osteoarthritis (OA) has long been considered as a cartilage disease. However, it is now well established that cartilage defects are the ultimate OA feature only. Several studies investigating the mechanisms of OA onset/progression have recognized the infrapatellar fat pad as an active OA-player but also as a possible source of stem cells with regenerative potential for cartilage. Is it really like that? a cautious approach should be adopted.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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