Orthobiologics in 2025 and Beyond.
Shapiro SA., Giusti N., Lopez A., Rodeo S., Cole BJ., Arthurs J.
Laboratory Study on Hip, published in Instr Course Lect (2026) — summary generated from the PubMed abstract.
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Instr Course Lect (2026)
- Country
- United States
- Reported sample size
- —
- PMID
- 41289438
Abstract (original English)
Orthobiologics are biologic substances intended to enhance healing and treat a range of musculoskeletal pathologies. Commonly well-studied orthobiologics such as platelet-rich plasma, bone marrow aspirate concentrate, and micro-fragmented adipose tissue have more than 2 decades of scientific research and clinical use, although with variable outcomes. It is important to discuss both current utilization and future applications of the aforementioned orthobiologics while elucidating some novel orthobiologics with recent regulatory approval, and finally, those orthobiologics on the horizon and beyond. Orthopaedic applications of mesenchymal stem or stromal cells, cell-based cartilage implants, and perinatal cell-derived therapies all hold promise to treat a broad range of musculoskeletal ailments. The Biologic Association and American Academy of Orthopaedic Surgeons are at the forefront of these emerging technologies, cooperating together on behalf of their membership to provide resources for the purpose of scientific discovery, clinical validation, and translation of novel orthobiologic therapies.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence comes from animal or laboratory studies and has not been confirmed in humans.
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J Am Heart Assoc - Level ASystematic Review
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Systematic Review with a reported sample of 602 on Knee Osteoarthritis, Osteoarthritis, Chronic Inflammation, Immune Modulation, published in PeerJ (2026) — summary generated from the PubMed abstract.
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PeerJ - Level AMeta-analysis
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