Orthobiologics: Injectable Treatments for Knee Osteoarthritis.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Autologous therapies with intra-articular orthobiologic approaches have been introduced to address knee osteoarthritis (OA) patients. Among these, platelet-rich plasma (PRP) and cell-based injectable therapies obtained from bone marrow or adipose tissue are gaining a significant interest in the clinical practice. PRP is currently showing the highest support, in terms of overall number of data, superiority in comparative trials, and some support from scientific societies. On the other hand, bone marrow concentrates are currently the most used approach for subchondral bone injections, and adipose-derived treatments showed promise to address more advanced OA patients otherwise less responsive to other orthobiologic injectable options.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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