Platelet-rich plasma for treatment of knee osteoarthritis: a narrative review

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Osteoarthritis is the most common cause of arthritis, a pervasive condition affecting various joints within the human body. The culmination of various factors resulting in degradation and damage of healthy cartilage initiates the cascade of degenerative changes which contribute to the development of this condition, affecting about 73% of all adults older than age 55. Various treatments are available to help treat this condition. Prevention often includes the utilization of physical therapy, exercise, and weight management while treatment of the resultant joint pain includes bracing, medications, and interventional treatments including steroid and visco supplementation techniques. Within the past two decades, particular interest has developed in utilizing regenerative methods for treatment of these degenerative conditions. One such treatment is platelet rich plasma. Here we review the salient conceptions of this treatment and provide a brief overview of the evidence and healthcare impact regarding its utilization.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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