Research Progress of Combining High Tibial Osteotomy with Platelet-rich Plasma for Osteoarthritis Therapy

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

High tibial osteotomy (HTO) has been widely applied in clinical practice to treat unilateral knee osteoarthritis (OA). In order to improve the effectiveness of surgical treatment, researchers attempted to use a combination of platelet-rich plasma (PRP) and HTO therapy. We summarized the clinical outcomes of engaging HTO and PRP and found promising clinical advantages in improving postoperative pain and function, promoting cartilage repair, and increasing bone cartilage structure in patients. Further studies are needed to provide more convincing evidence of the efficacy of the combined therapy.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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