Stem cell-derived exosomes in tissue regeneration of oral and maxillofacial region: A systematic review

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Oral and maxillofacial diseases are often accompanied by tissue defects and damages, which are difficult to repair and affect patients both physically and psychologically as well as daily life. Recent 5 years studies have proved that stem cell-derived exosomes possess a broad clinical application in regenerative dentistry by promoting hard and soft tissue regeneration, angiogenesis, nerve repair, and wound healing, inhibiting inflammation and apoptosis, and modulating immune responses. The purpose of this review is to sum up the current state of research on stem cell-derived exosomes in periodontal regeneration and to discuss the current challenges and future directions. Methods This review article was conducted using electronic databases such as PubMed and Web of Science. The search included studies published up until January 1, 2025. Results Stem cell-derived exosomes are a kind of membrane vesicles that encapsulate proteins, RNAs, and other substances, which are one of the important strategies for tissue regeneration and repair. Stem cell-derived exosomes play an important role in the field of periodontal regeneration, including dental pulp, periodontium, jawbone, temporomandibular joint, maxillofacial soft tissue, and nerve. Mechanistically, stem cell-derived exosomes alleviate oral and maxillofacial diseases by promoting tissue regeneration, osteogenesis, odonto

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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