SVF
Level A· Stronger Clinical EvidenceSystematic Review

A Systematic Review of Case Series and Clinical Trials Investigating Regenerative Medicine for the Treatment of Vitiligo.

Jafarzadeh A., Mohammad AP., Goodarzi A.

Systematic Review with a reported sample of 2186 on Hair & Scalp, published in J Cosmet Dermatol (2025) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Systematic Review
Journal
J Cosmet Dermatol (2025)
Country
England
Reported sample size
2186
PMID
39509558
DOI
10.1111/jocd.16660

Abstract (original English)

The aim of this study is to examine the efficacy and safety of various regenerative medicine treatments, such as cell therapy, platelet-rich plasma (PRP), plasma-poor platelet (PPP), plasma-rich fibrin (PRF), mesenchymal stem cells, stromal vascular fraction (SVF), exosomes, adipose-derived stem cells (ADSC), and stem cell-conditioned media (SC-CM), for treating vitiligo. We conducted a thorough search of major databases such as PubMed, Scopus, and Web of Science, and selected 48 articles based on specific criteria. We used EndNote X8 and Google Sheets to review and extract data from the articles. After analyzing the studies, we categorized them accordingly. This systematic review analyzed 48 articles involving 2186 patients with vitiligo to assess the effectiveness of regenerative medicine treatments. Key findings revealed that methods such as autologous non-cultured melanocyte-keratinocyte transplantation and platelet-rich plasma (PRP) injection exhibited significant repigmentation, particularly when combined with modalities like NB-UVB phototherapy and laser treatments. Notably, the autologous melanocyte-keratinocyte transplantation achieved over 50% repigmentation within 9 months, while PRP demonstrated an average repigmentation of 58.7%, especially effective with CO 2 laser treatment. Hair follicle-derived cell transplantation also showed impressive response rates, achievi

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
HumansVitiligoRegenerative MedicinePlatelet-Rich PlasmaMelanocytesKeratinocytesTreatment OutcomeClinical Trials as TopicStem Cell TransplantationTransplantation, Autologous
Hair & Scalp
View on PubMedDOI

Related research