SVF
Level A· Stronger Clinical EvidenceSystematic Review

Systematic review of exosome treatment in hair restoration: Preliminary evidence, safety, and future directions.

Gupta AK., Wang T., Rapaport JA.

Systematic Review on Hair Loss, Hair Regeneration, published in J Cosmet Dermatol (2023) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Systematic Review
Journal
J Cosmet Dermatol (2023)
Country
England
Reported sample size
—
PMID
37381168
DOI
10.1111/jocd.15869

Abstract (original English)

Exosomes are small extracellular vesicles with potential roles in modulating the hair growth cycle and are an emerging therapy for patients with alopecia. In recent years, researchers have made significant progress in deciphering the network of cellular interactions and signaling pathways mediated by the transfer of exosomes. This has opened the door to a wide range of potential therapeutic applications with an increasing focus on its application in precision medicine. To evaluate current published evidence, both preclinical and clinical, on the use of exosomes for hair restoration. In January 2023, a systematic search was conducted using PubMed, Embase, and the Cochrane Library. Records were identified, screened, and assessed for eligibility as per the PRISMA guideline. We identified 16 studies (15 preclinical and 1 clinical) showing varying degrees of efficacy using exosomes derived from sources including adipose-derived stem cells (ADSCs) and dermal papilla cells (DPCs). Applications of exosomes isolated from ADSCs (ADSC-Exo) and DPCs have shown early promising results in preclinical studies corroborated by results obtained from different model systems. Topical ADSC-Exo has been tried successfully in 39 androgenetic alopecia patients demonstrating significant increases in hair density and thickness. No significant adverse reactions associated with exosome treatment have been

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
HumansExosomesAdipose TissueHairAdipocytesAlopecia
Hair & ScalpHair LossHair Regeneration
View on PubMedDOI

Related research