Adipose-derived stem cell exosomes: from functional mechanisms to clinical translation in diabetic foot ulcer management.
Zhong X., Wu G.
Narrative Review on Diabetic Foot, Chronic Wound, published in Front Endocrinol (Lausanne) (2026) — summary generated from the PubMed abstract.
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Front Endocrinol (Lausanne) (2026)
- Country
- Switzerland
- Reported sample size
- —
- PMID
- 42290854
- DOI
- 10.3389/fendo.2026.1795114
Abstract (original English)
Diabetes is a major global public health challenge. Diabetic foot ulcer (DFU), one of its most severe complications, imposes a substantial economic burden and severely impairs patients' quality of life. Current treatment strategies often yield suboptimal outcomes, underscoring the urgent need for novel therapeutic approaches. Adipose-derived stem cell exosomes (ADSC-Exos) have emerged as a promising cell-free therapy with significant clinical potential. This review integrates the mechanisms through which ADSC-Exos facilitate diabetic wound healing with the phases of wound healing. It elucidates that ADSC-Exos function by alleviating oxidative stress, modulating inflammation, promoting angiogenesis, stimulating cell proliferation and migration, and suppressing excessive fibrosis. Additionally, this study organizes insights into how delivery strategies based on smart materials (e.g., hydrogels and bioscaffolds) and the latest physical modalities can overcome bottlenecks in clinical translation. This review aims to provide an integrated perspective for developing next-generation DFU therapies.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
There is currently not enough data to draw conclusions about benefit or risk for this topic.
How we grade evidenceRelated research
- Level AMeta-analysis
Therapeutic Effect of Stem Cells from Different Sources on Diabetic Foot Ulcers: Systematic Review and Network Meta-Analysis.
Meta-analysis on Ankle Injury, Diabetic Foot, Chronic Wound, published in Int J Low Extrem Wounds (2026) — summary generated from the PubMed abstract.
- 2026
Int J Low Extrem Wounds - Level AMeta-analysis
Efficacy of Stem Cell-Derived Exosomes in Promoting Diabetic Foot Ulcer Healing: A Meta-Analysis of Preclinical Animal Studies.
Meta-analysis on Diabetic Foot, Chronic Wound, published in J Diabetes Res (2026) — summary generated from the PubMed abstract.
- 2026
J Diabetes Res - Level AMeta-analysis
Role of Adipose Derived Stem Cells in Patients with Diabetic Foot Ulcers: Systematic Review and Meta-Analysis of Randomised Controlled Trials.
Meta-analysis with a reported sample of 81 on Diabetic Foot, Chronic Wound, published in Int J Low Extrem Wounds (2025) — summary generated from the PubMed abstract.
- 2025
- n = 81
Int J Low Extrem Wounds - Level ASystematic Review
Therapeutic potential of adipose-derived stem cells for diabetic foot ulcers: a systematic review and meta-analysis.
Systematic Review on Diabetic Foot, Chronic Wound, published in Diabetol Metab Syndr (2025) — summary generated from the PubMed abstract.
- 2025
Diabetol Metab Syndr - Level AMeta-analysis
A meta-analysis on application and prospect of cell therapy in the treatment of diabetes mellitus.
Meta-analysis on Diabetic Foot, Autoimmune Research, published in Stem Cell Res Ther (2025) — summary generated from the PubMed abstract.
- 2025
Stem Cell Res Ther - Level ASystematic Review
Effects of Nanofat in Plastic and Reconstructive Surgery: A Systematic Review.
Systematic Review with a reported sample of 253 on Diabetic Foot, Chronic Wound, Scar, Skin Aging, published in Plast Reconstr Surg (2024) — summary generated from the PubMed abstract.
- 2024
- n = 253
Plast Reconstr Surg