[Advances in the research of influence of diabetes in biological function of adipose-derived stem cells].

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Adipose-derived stem cells (ADSCs) are adult mesenchymal stem cells in adipose tissue with self-renewal and multi-directional differentiation potential. The application of ADSCs in the treatment of wounds has achieved good results. Because of its extensive sources, high content in vivo, low immunogenicity, slight injury to body when obtained, the clinical application prospect of ADSCs is promising. The reasons why diabetic wound is difficult to heal may be closely related to the increase of advanced glycation end products, long-term chronic inflammatory response, and peripheral neurologic dysfunction. The abnormal internal environment of diabetic patients can affect the biological function of ADSCs, which further affects wound healing. This article reviews the general feature, differentiation, proliferation, migration, secretion, and pro-angiogenic function of diabetic ADSCs. 脂肪源性间充质干细胞(ADSC)是存在于脂肪组织中的具有自我更新和多向分化潜能的成体间充质干细胞。ADSC在创面治疗方面已经取得了良好的效果，且因其有来源广泛、体内含量多、免疫原性低、获取对机体创伤小等优势，临床应用前景十分广泛。糖尿病创面愈合困难的原因可能与晚期糖基化终末产物增多、长期的慢性炎症反应及外周神经功能障碍密切相关。糖尿病患者异常的体内环境也可影响ADSC的生物学功能，从而影响创面愈合。本文就糖尿病ADSC的一般特性及其分化、增殖、迁移、分泌及促血管生成功能进行综述。.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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