Clinical Efficacy of Adipose-Derived Stem Cell-Enriched Lipotransfer Versus Conventional Fat Grafting: A Systematic Review and Meta-Analysis.

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Autologous fat grafting is a standard procedure for soft tissue reconstruction, yet its clinical utility is often compromised by unpredictable resorption rates. Cell-assisted lipotransfer (CAL), which enriches fat grafts with adipose-derived stem cells (ASCs) or stromal vascular fraction (SVF), has been proposed to stabilise retention through improved neovascularisation and paracrine support. This systematic review evaluates the clinical efficacy, safety, and oncological outcomes of CAL compared to conventional lipofilling. A systematic literature search was conducted across PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, Excerpta Medica database (EMBASE), and Cochrane Library databases following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Inclusion criteria were randomised controlled trials (RCTs) and cohort studies comparing enriched versus non-enriched fat grafts in humans. The primary outcome was volumetric retention, while secondary outcomes included complications and oncological safety. A random-effects meta-analysis was performed using Stata 15.1 (StataCorp LLC, College Station, TX) and Simple Meta-Analysis software (Learn Meta-Analysis LLC) to calculate standardised mean differences (SMD), and heterogeneity was assessed using Cochran's Q and the I² statistic. Fifteen studies meet

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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