SVF
Level A· Stronger Clinical EvidenceSystematic Review

Effects of Nanofat in Plastic and Reconstructive Surgery: A Systematic Review.

Tran VVT., Jin X., Hong KY., Chang H.

Systematic Review with a reported sample of 253 on Diabetic Foot, Chronic Wound, Scar, Skin Aging, published in Plast Reconstr Surg (2024) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Systematic Review
Journal
Plast Reconstr Surg (2024)
Country
United States
Reported sample size
253
PMID
37400953
DOI
10.1097/PRS.0000000000010905
NCT
NCT03328871

Abstract (original English)

Since nanofat was first introduced by Tonnard in 2013, numerous studies have reported positive findings with its use; however, concerns exist regarding its effects and mechanisms, and the various methods used to generate nanofat also remain unclear. The authors conducted a systematic review to evaluate the efficacy of nanofat grafting alone in plastic and reconstructive surgery. The MEDLINE, Embase, Cochrane Central, Web of Science, and Scopus databases were searched for studies related to the use of nanofat grafting alone in plastic and reconstructive surgery. Outcomes of interest were all clinical results in humans or animals. Twelve studies were included. No meta-analysis was conducted due to the clinical heterogeneity of the studies. In general, included studies had a low level of evidence. Six studies ( n = 253 patients) showed significant improvements in scar characteristics based on Patient and Observer Scar Assessment Scale, FACE-Q scale, physician assessment, patient satisfaction, and Vancouver Scar Scale scores. Four studies described the benefits of nanofat in skin rejuvenation (wrinkles, fine rhytides, pigmentation, and discoloration) through photographs, questionnaires, and indentation indices. Histologic evaluation illustrated overall increases in skin thickness, collagen, and elastic fibers. Three experimental studies showed the beneficial effects of nanofat on f

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
HumansPlastic Surgery ProceduresAdipose TissueRejuvenationAnimalsSkin AgingCicatrixTreatment OutcomeCosmetic TechniquesPatient Satisfaction
Face & SkinHair & ScalpDiabetic FootChronic WoundScarSkin Aging
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