Evaluation of the Effect of Different Mesenchymal Stem Cell Microvesicles on Diabetic Wound Healing.

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Objective Mesenchymal stem cell (MSC)-derived microvesicles play a pivotal role in the regenerative cascade of wound healing. This study aimed to comparatively evaluate the therapeutic potential of microvesicles isolated from different MSC sources in the healing of diabetic cutaneous wounds. Materials and methods Forty Wistar albino rats were randomly assigned to four experimental groups (n=10 per group). Following the induction of diabetes and the creation of full-thickness circular dorsal skin defects, each group received a distinct treatment: Group 1 received saline (control), Group 2 received adipose-derived stem cell microvesicles (ADSC-MVs), Group 3 received umbilical cord-derived stem cell microvesicles (UCDSC-MVs), and Group 4 received bone marrow-derived stem cell microvesicles (BMDSC-MVs). Outcomes related to re-epithelialization, neovascularization, and collagen matrix formation were evaluated both macroscopically and histologically. Results The microvesicle-treated groups demonstrated faster wound closure and improved collagen fiber alignment compared with the control group. Angiogenic activity was increased in all treatment groups, with the most pronounced effects observed in the UCDSC-MVs group. Notably, the UCDSC-MVs group exhibited a significantly greater epithelial tongue length than the control group on postoperative days 3 and 14 (p=0.008 and p Conclusion The

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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